Abstract Search

ea0027p43 | (1) | BSPED2011

Chemotherapy treatment for medulloblastoma is associated with increased risk of impaired gonadal function

Bischof-Renner Andrea , Su Zhe , Edgar Angela B , Mitchell Rod T , Wallace W H , Bath Louise E

Introduction: Effects on fertility have been seen as important late effects of treatment for childhood cancer.Aim: To evaluate the impact of chemotherapy and radiotherapy treatment for childhood medulloblastoma on gonadal function.Methods: Retrospective cohort study of all children treated for medulloblastoma (diagnosed from 218 years) in a single institution in the UK between 19832011 and a minimum relapse-free surviva...

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ea0031p291 | Pituitary | SFEBES2013

Is diethylstilboestrol an endocrine disruptor in the developing human fetal testis? Effects of DES exposure using a xenograft approach

Mitchell R T , Anderson R A , van den Driesche S , McKinnell C , MacPherson S , Wallace W H B , Kelnar C J H , Sharpe R M

Context: In rodents, in-utero exposure to the exogenous oestrogen diethylstilboestrol (DES) results in reproductive abnormalities in male offspring. It has been proposed that similar anti-androgenic effects also occur in the human fetal testis following oestrogen exposure.Objective: Determine effects of DES exposure on testosterone production by normally growing human fetal testis xenografts.Design: Human fetal testes (15&...

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Endocrine Abstracts

Chemotherapy treatment for medulloblastoma is associated with increased risk of impaired gonadal function

Is diethylstilboestrol an endocrine disruptor in the developing human fetal testis? Effects of DES exposure using a xenograft approach

BiosciAbstracts